The Speaker：Prof. Pai-Chi Li 李百祺 National Taiwan University
Time: 2016/1/6, 16:00-16：50 pm
Location: 海韵校区物理机电航空大楼438会议室
Abstract: Ultrasound has been widely used for preclinical research. In this talk, we will present our recent works on the use of ultrasound in two particular areas: acoustic based theranostic technologies and shear wave elasticity imaging of 3D cell culture systems. The acoustic based theranostic technologies are regarding the combination of ultrasound and photoacoustic/photothermal effects for synergistic delivery of gold nanoparticles (AuNPs) using multifunctional microbubbles for enhanced plasmonic photothermal therapy (PPTT). PPTT using AuNPs as efficient photoabsorbing agents has been proposed and one critical step is to effectively deliver AuNPs into the cells. We demonstrated that the delivery of AuNPs can be greatly enhanced by combining the following three mechanisms: AuNPs encapsulated in protein-shell microbubbles/nanodroplets, molecular targeting, and sonoporation employing acoustic cavitation. The PPTT results in vivo showed that the temperature increase provided a sufficiently high degree of hyperthermia.
Biography: Pai-Chi Li received the Ph.D. degree in Electrical Engineering: Systems, from the University of Michigan, Ann Arbor in 1994. He joined Acuson Corporation, Mountain View, CA, as a member of the Technical Staff in June 1994. In August 1997, he went back to the Department of Electrical Engineering at National Taiwan University, where he is currently Associate Dean of College of Electrical Engineering and Computer Science, Distinguished Professor of Department of Electrical Engineering and Institute of Biomedical Electronics and Bioinformatics. He served as Founding Director of Institute of Biomedical Electronics and Bioinformatics in 2006-2009 and National Taiwan University YongLin Biomedical Engineering Center in 2009-2011. He is also TBF Chair in Biotechnology. Dr. Li is IEEE Fellow, IAMBE Fellow, AIUM Fellow and SPIE Fellow. He was also Editor-in-Chief of Journal of Medical and Biological Engineering, and Associate Editor of Ultrasound in Medicine and Biology.
